The world of legal hemp has been expanding with tremendous speed, and it’s great to see so many people and governments embracing the wonderful possibilities of this incredible plant. At Hempstead Farms, we strongly believe in the importance of education within the CBD industry – because being properly informed about the specific wellness potential of compounds such as CBD is crucial to removing the stigma that has been unfairly associated with hemp for such a long time.
Our goal is to make Hempstead Farms your safe haven when it comes to proving trusted CBD products while also giving our clients access to important information about the science of hemp. In our previous blog, we covered endocannabinoids, enzymes and cannabinoid receptors as they relate to the endocannabinoid system.
Let’s now take a closer look at cannabinoid receptors CB1 & CB2.
CB1 Receptors & the Endocannabinoid System
CB1 are the first receptors that were discovered in the middle of the 20th century, and with the opportunity for enhanced research, we now know more about them and how they work to help our bodies and minds.
Here’s what we know so far about CB1 cannabinoid receptors:
- They are G protein-coupled cannabinoid receptors.
- Found primarily in the central nervous system, but also located in the endocrine glands, spleen, heart, and other locations of the peripheral nervous system.
- Activated by the endocannabinoid neurotransmitters anandamide and 2-arachidonoylglycerol (2-AG).
- Also activated by external cannabinoids such as CBD.
- Responsible for inhibiting neurotransmitter release and mediating the psychoactive effects of cannabinoids.
CB2 Receptors & the Endocannabinoid System
The second cannabinoid receptors to be discovered are collectively known as CB2 receptors. Their presence has further illuminated the endocannabinoid system and has allowed us to learn more about our delicate biological makeup.
Here’s what we know about CB2 cannabinoid receptors:
- They are also G protein-coupled cannabinoid receptors.
- Located mostly in the peripheral nervous system.
- Also present in the brain and gastrointestinal system.
- Closely associated with the immune system and inflammation response.
- CB2 activation is known to relax the body and help it repair itself by reducing the feeling of pain but without affecting cognition.
CB1/CB2 Receptors & Cannabidiol (CBD)
Now that we’ve covered some particulars about cannabinoid receptors CB1 and CB2, let’s now talk about how CBD, or cannabidiol, interacts with our body in order to bring relief.
Here are some important facts relating to what we know about the process by which CBD interacts with cannabinoid receptors CB1 and CB2:
- CBD helps cannabinoid receptors to regulate the balance of daily bodily functions.
- CBD doesn’t bind directly with either CB1 or CB2 receptors, however it does stimulate both.
- CBD is a partial agonist (a substance which initiates a physiological response) of the CB2 receptor.
- CBD has low affinity for the CB1 orthosteric (active state) site and is a CB1 agonist.
- CBD appears to have fluid affinity for both the allosteric (inactive state) and orthosteric (active state) sites at CB1 receptors, depending on if another ligand is activating the receptor or not.
Hempstead Farms: Your CBD Safe Haven
Your wellness is our #1 priority, and so we’re proud to provide our clients with organically-grown, non-GMO hemp farmed in Kentucky. Why choose organic hemp for our products?
It’s simple: because there is absolutely no dangerous bacteria, heavy metals, or pesticides in the hemp plants, which means that what you’re getting is the best it can be. Since we are a small, family-owned company, we keep a close eye on everything associated with our operations while also using the cleanest, purest extraction method to formulate our products.
Always consult a physician before making any changes to your health or fitness regimen.